Friday, November 16

HEPATITIS C

NATURAL COURSE OF HEPATITIS C

HEPATITIS C
In patients with hepatitis C infection, 25-50% clears the infection spontaneously. These are diagnosed by positive anti-HCV antibodies and negative HCV RNA. These patients also have normal liver enzyme levels. More women clear the infection then men. Patients who develop chronic HCV usually have nonspecific symptoms such as malaise and fatigue. On investigation these patients have elevated ALT levels along with positive HCV RNA .These patients may also present with some extra hepatic symptoms and signs such as -diabetes mellitus, rheumatoid arthritis, keratoconjuctivitis sicca, mixed cryoglobulinemia, membranoproliferative glomerulonephritis, nephrotic syndrome, and porphyria cutanea tarda. Many factors have been seen to be associated with the progression of disease and fibrosis of l...